Leper's Curse
The Atharva-Veda includes several charms to cure leprosy... but a Brahmin can reverse a sacred rite and turn it into a curse upon an enemy. To curse a mortal with leprosy, a sadhu calls upon Agru, Indra and other gods of light and life to deliver the victim unto Nirriti, the goddess of misery and destruction.
System: If the sadhu performs the curse correctly, the mortal victim contracts leprosy within a week. This is true leprosy, not a magical simulation. The leprosy-curing spell from the Atharva-Veda can remove the curse, however, if the victim uses it within one month of contracting the disease.